CTAP is an antagonist at μ-opioid receptors (μORs) that exhibits neuromodulatory activity. CTAP prevents reinstatement of drug seeking in animal models of ethanol addiction. CTAP also prevents opioid-induced decreases in inflammatory cytokine release in animal models of intestinal ischemia/reperfusion. Additionally, CTAP inhibits opioid-induced analgesia in animal models of colorectal distension.
| Purity | ≥95% |
|---|---|
| Formula | C51H67N13O11S |
| Formula Wt. | 1102.33 |
| IUPAC Name | (4R,7S,10S,13S,16S,19R)-N-[(2S,3R)-1-amino-3-hydroxy-1-oxobutan-2-yl]-19-[[(2S)-2-amino-3-phenylpropanoyl]amino]-10-[3-(diaminomethylideneamino)propyl]-7-[(1R)-1-hydroxyethyl]-16-[(4-hydroxyphenyl)methyl]-13-(1H-indol-3-ylmethyl)-3,3-dimethyl-6,9,12,15,18-pentaoxo-1,2-dithia-5,8,11,14,17-pentazacycloicosane-4-carboxamide |
| Store Temp | -20°C |
|---|---|
| Ship Temp | Ambient |
| Info Sheet | C7602 Info Sheet PDF |
|---|
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Saccani F, Anselmi L, Jaramillo I, et al. Protective role of μ opioid receptor activation in intestinal inflammation induced by mesenteric ischemia/reperfusion in mice. J Neurosci Res. 2012 Nov;90(11):2146-53. PMID: 22806643.
Distrutti E, Cipriani S, Renga B, et al. Hydrogen sulphide induces micro opioid receptor-dependent analgesia in a rodent model of visceral pain. Mol Pain. 2010 Jun 11;6:36. PMID: 20540729.
