Description
CZC-54252isaninhibitorofleucine-richrepeatkinase2(LRRK2)thatexhibitsneuroprotectiveactivity.ThiscompoundmaydecreaseneuronalinjuryinmodelsofneurodegenerativediseasessuchasParkinson’sdisease.
CZC-54252isaninhibitorofleucine-richrepeatkinase2(LRRK2)thatexhibitsneuroprotectiveactivity.ThiscompoundmaydecreaseneuronalinjuryinmodelsofneurodegenerativediseasessuchasParkinson’sdisease.
| CasNo. | 1191911-27-9 |
|---|---|
| Purity | ≥98% |
| Formula | C22H25ClN6O4S |
| FormulaWt. | 504.99 |
| IUPACName | N-{2-[(5-Chloro-2-{[2-methoxy-4-(4-morpholinyl)phenyl]amino}-4-pyrimidinyl)amino]phenyl}methanesulfonamide |
| StoreTemp | -20°C |
|---|---|
| ShipTemp | Ambient |
| InfoSheet | C9808InfoSheetPDF |
|---|---|
| Brochures | LRRK2Flyer |
KramerT,LoMonteF,GöringS,etal.SmallmoleculekinaseinhibitorsforLRRK2andtheirapplicationtoParkinson"sdiseasemodels.ACSChemNeurosci.2012Mar21;3(3):151-60.PMID:22860184.
RaMSDenN,PerrinJ,RenZ,etal.Chemoproteomics-baseddesignofpotentLRRK2-selectiveleadcompoundsthatattenuateParkinson"sdisease-relatedtoxicityinhumanneurons.ACSChemBiol.2011Oct21;6(10):1021-8.PMID:21812418.