Description
Dapoxetine hydrochloride was initially designed as an antidepressant but was found more beneficial in the treatment of premature ejaculation due to its lack of significant effects on mood and quick adsorption and elimination kinetics. Dapoxetine is a centrally-acting SSRI that modulates serotonin levels in relevant areas such as the lateral paragigantocellular nucleus through inhibition of the serotonin transporter (SERT). This compound also decreases peak amplitude and accelerates the decay rate of current inactivation in a variety of voltage-gated K+ channels.
References
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Jeong I, Yoon SH, Hahn SJ. Effects of dapoxetine on cloned Kv1.5 channels expressed in CHO cells. Naunyn Schmiedebergs Arch Pharmacol. 2012 Jul;385(7):707-16. PMID: 22568341.
Jeong I, Kim SW, Yoon SH, et al. Block of cloned Kv4.3 potassium channels by dapoxetine. Neuropharmacology. 2012 Jun;62(7):2261-6. PMID: 22192593.
Clément P, Bernabé J, Gengo P, et al. Supraspinal site of action for the inhibition of ejaculatory reflex by dapoxetine. Eur Urol. 2007 Mar;51(3):825-32. PMID: 17064843.
