Description
DAPT is a γ-secretase inhibitor that suppresses Notch signaling and exhibits neuroprotective and anticancer activities. DAPT inhibits proliferation of cancer stem cells.
DAPT is a γ-secretase inhibitor that suppresses Notch signaling and exhibits neuroprotective and anticancer activities. DAPT inhibits proliferation of cancer stem cells.
| Cas No. | 208255-80-5 |
|---|---|
| Purity | ≥98% |
| Formula | C23H26F2N2O4 |
| Formula Wt. | 432.47 |
| IUPAC Name | 2-Methyl-2-propanyl (2S)-({N-[(3,5-difluorophenyl)acetyl]-L-alanyl}amino)(phenyl)acetate |
| Synonym | GSI-IX |
| Appearance | White to off white powder |
| Store Temp | -20°C |
|---|---|
| Ship Temp | Ambient |
| Info Sheet | D0260 Info Sheet PDF |
|---|
Liu J, Mao Z, Huang J, et al. Blocking the NOTCH pathway can inhibit the growth of CD133-positive A549 cells and sensitize to chemotherapy. Biochem Biophys Res Commun. 2014 Feb 21;444(4):670-5. PMID: 24502949.