Description
DAPT is a γ-secretase inhibitor that suppresses Notch signaling and exhibits neuroprotective and anticancer activities. DAPT inhibits proliferation of cancer stem cells.
DAPT is a γ-secretase inhibitor that suppresses Notch signaling and exhibits neuroprotective and anticancer activities. DAPT inhibits proliferation of cancer stem cells.
Cas No. | 208255-80-5 |
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Purity | ≥98% |
Formula | C23H26F2N2O4 |
Formula Wt. | 432.47 |
IUPAC Name | 2-Methyl-2-propanyl (2S)-({N-[(3,5-difluorophenyl)acetyl]-L-alanyl}amino)(phenyl)acetate |
Synonym | GSI-IX |
Appearance | White to off white powder |
Store Temp | -20°C |
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Ship Temp | Ambient |
Info Sheet | D0260 Info Sheet PDF |
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Liu J, Mao Z, Huang J, et al. Blocking the NOTCH pathway can inhibit the growth of CD133-positive A549 cells and sensitize to chemotherapy. Biochem Biophys Res Commun. 2014 Feb 21;444(4):670-5. PMID: 24502949.