Description
Delta sleep-inducing peptide exhibits anticonvulsant/antiepileptic and neuromodulatory activities. In vivo, this peptide decreases the incidence, severity, and duration of metaphit-induced seizures. Delta sleep-inducing peptide potentiates GABA currents and inhibits potentiation of NMDA currents in vivo. Additionally, this peptide exhibits hypoglycemia-like properties in other animal models, inhibiting non-enzymatic glycosylation of hemoglobin and decreasing protein oxidation. In myoleukemia cells, delta sleep-inducing peptide decreases expression of HSP70.
References
Bondarenko TI, Sorokina IA, Mayboroda EA, et al. Effect of delta sleep-inducing peptide on oxidative modification of proteins in rat tissues and blood during physiological aging. Bull Exp Biol Med. 2012 Jul;153(3):371-4. PMID: 22866315.
Nurbakov AA, Mikhaleva II, Sapozhnikov AM. Effect of delta-sleep-inducing peptide on expression of heat shock protein 70 kDa in K562 cells. Bull Exp Biol Med. 2009 Jan;147(1):39-41. PMID: 19526126.
Grigor'ev VV, Ivanova TA, Kustova EA, et al. Effects of delta sleep-inducing peptide on pre- and postsynaptic glutamate and postsynaptic GABA receptors in neurons of the cortex, hippocampus, and cerebellum in rats. Bull Exp Biol Med. 2006 Aug;142(2):186-8. PMID: 17369935.
Stanojlović OP, Zivanović DP, Mirković SD, et al. Antiepileptic activity of delta sleep-inducing peptide and its analogue in metaphit-provoked seizures in rats. Seizure. 2005 Jun;14(4):240-7. PMID: 15911358.
