DermenkephalinisanexogenousopioidpeptidethatactsasanagoNISTatδ-opioidreceptors(selectiveforδ-2receptors).Dermenkephalin,likeotherδORagonists,exhibitsantinociceptive/analgesicactivity,increasingresponselatencyinanimalmodelsofthermalpain.Dermenkephalinalsoplaysaroleinrewardandreinforcementsignaling,inducingconditionedplacepreferenceinanimalmodelspreviouslyadministeredethanolorcocaine.Dermenkephalinalsoincreaseslocomotoractivityinanimalmodels.
| CasNo. | 119975-64-3 |
|---|---|
| Purity | ≥95% |
| Formula | C44H62N10O10S2 |
| FormulaWt. | 955.17 |
| IUPACName | (3S)-4-amino-3-[[(2S)-2-[[(2S)-2-[[(2S)-2-[[(2S)-2-[[(2R)-2-[[(2S)-2-amino-3-(4-hydroxyphenyl)propanoyl]amino]-4-methylsulfanylbutanoyl]amino]-3-phenylpropanoyl]amino]-3-(1H-imidazol-5-yl)propanoyl]amino]-4-methylpentanoyl]amino]-4-methylsulfanylbutanoyl]amino]-4-oxobutanoicacid |
| Appearance | Whitetooffwhitepowder |
| StoreTemp | -20°C |
|---|---|
| ShipTemp | Ambient |
| MSDS | D1767MSDSPDF |
|---|---|
| InfoSheet | D1767InfoSheetPDF |
MitchellJM,MargolisEB,CokerAR,etal.Intra-VTAdeltorphin,butnotDPDPE,inducesplacepreferenceinethanol-drinkingrats:distinctDOR-1andDOR-2mechanismscontrolethanolconsumptionandreward.AlcoholClinExpRes.2014Jan;38(1):195-203.PMID:24033469.
FraserGL,ParenteauH,TuTM,etal.TheeffectsofdeltaagonistsonlocomotoractivityinhABItuatedandnon-habituatedrats.LifeSci.2000Jul14;67(8):913-22.PMID:10946851.
HarasawaI,FieldsHL,MengID.Deltaopioidreceptormediatedactionsintherostralventromedialmedullaontailflicklatencyandnociceptivemodulatoryneurons.Pain.2000Mar;85(1-2):255-62.PMID:10692626.
