Dermorphinisanopioidpeptideoriginallyfoundintheskinofamphibians;itexhibitsanalgesicandantinociceptiveactivities,actingasanagoNISTatμ-opioidreceptors(μORs).Inanimalmodelsofthermal,mechanical,andchemicalpain,dermorphinincreasespainthresholds.
| CasNo. | 77614-16-5 |
|---|---|
| Purity | ≥96% |
| Formula | C40H50N8O10 |
| FormulaWt. | 802.88 |
| ChemicalName | Tyrosyl-alanyl-phenylalanyl-glycyl-tyrosyl-prolyl-serinamide |
| IUPACName | (2S)-N-[(2S)-1-amino-3-hydroxy-1-oxopropan-2-yl]-1-[(2S)-2-[[2-[[(2S)-2-[[(2R)-2-[[(2S)-2-amino-3-(4-hydroxyphenyl)propanoyl]amino]propanoyl]amino]-3-phenylpropanoyl]amino]acetyl]amino]-3-(4-hydroxyphenyl)propanoyl]pyrrolidine-2-carboxamide |
| Appearance | Whitetooffwhitepowder |
| StoreTemp | -20°C |
|---|---|
| ShipTemp | Ambient |
| MSDS | D1769MSDSPDF |
|---|---|
| InfoSheet | D1769InfoSheetPDF |
MizoguchiH,BagettaG,SakuradaT,etal.Dermorphintetrapeptideanalogsaspotentandlong-lastinganalgesicswithpharmacologicalprofilesdistinctfrommorphine.Peptides.2011Feb;32(2):421-7.PMID:21126548.
GuzevatykhLS,VoroninaTA,Emel"ianovaTG,etal.Comparativeanalysisofanalgesicactivitiesofdermorphin,[DPro6]-dermorphin,andtheirC-terminaltripeptides.IzvAkadNaukSerBiol.2007Sep-Oct;(5):577-82.PMID:18038625.
