Desvenlafaxineisanactivemetaboliteofvenlafaxine,displayingneuromodulatoryandantidepressantactivitiesthroughitsinhibitionofSEROtoninandnorepinephrinetransporters(SERT,NET).Duetoitsmodulationofserotoninlevels,desvenlafaxinealtersratesofgastricemptying;tolerancetothiseffectdevelopsquicklyduringchronicadmiNISTration.Thiscompoundisalsoinclinicaltrialsasapotentialtreatmentformenopausalhotflashes.
| CasNo. | 386750-22-7 |
|---|---|
| Purity | ≥99% |
| Formula | C16H25NO2•C4H6O4•H2O |
| FormulaWt. | 399.48 |
| ChemicalName | 4-[2-(Dimethylamino)-1-(1-hydroxycyclohexyl)ethyl]-phenolsuccinate |
| IUPACName | butanedioicacid;4-[2-(dimethylamino)-1-(1-hydroxycyclohexyl)ethyl]phenol;hydrate |
| Synonym | Pristiq |
| Appearance | Whitetooffwhitepowder |
| StoreTemp | Ambient |
|---|---|
| ShipTemp | Ambient |
| MSDS | D1874MSDSPDF |
|---|---|
| InfoSheet | D1874InfoSheetPDF |
SongJ,YinJ,ChenJD.Acuteandchroniceffectsofdesvenlafaxineongastrointestinaltransitandmotilityindogs.NeurogastroenterolMotil.2013Jul19.[Epubaheadofprint].PMID:23865827.
SunZ,HaoY,ZhangM.Efficacyandsafetyofdesvenlafaxinetreatmentforhotflashesassociatedwithmenopause:ameta-analysisofrandomizedcontrolledtrials.GynecolObstetInvest.2013;75(4):255-62.PMID:23548358.
DeMartinisNA,YeungPP,EntsuahR,etal.Adouble-blind,placebo-controlledstudyoftheefficacyandsafetyofdesvenlafaxinesuccinateinthetreatmentofmajordepressivedisorder.JClinPsychiatry.2007May;68(5):677-88.PMID:17503976.
DeecherDC,BeyerCE,JohnstonG,etal.Desvenlafaxinesuccinate:Anewserotoninandnorepinephrinereuptakeinhibitor.JPharmacolExpTher.2006Aug;318(2):657-65.PMID:16675639.
