Description
Diallyl sulfide is an organosulfur initially found in garlic; it exhibits anticancer chemotherapeutic, chemopreventive, neuroprotective, anti-inflammatory, antioxidative, anti-angiogenic, and anti-metastatic activities. Diallyl sulfide decreases DES-induced DNA damage and carcinogenesis in vitro and in vivo; it also inhibits the development of colon polyps in other carcinogenesis models. In animal models of cerebral ischemia/reperfusion, diallyl sulfide decreases infarct volume, apoptosis, and caspase 3 activation and increases levels of Bcl-2. In vitro, this compound decreases TNF-α-induced activation of NF-κB and suppresses histamine-induced levels of ROS, IL-1β, and TNF-α. Like other organosulfurs, diallyl sulfide induces phase II enzymes, increasing glutathione-S-transferase, glutathione reductase, superoxide dismutase, catalase, glutathione peroxidase, and Nrf2 in vivo. In animal models of osteosarcoma, diallyl sulfide decreases VEGF levels, microvessel density, cellular invasion, and tumor growth.
References
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Lin X, Yu S, Chen Y, et al. Neuroprotective effects of diallyl sulfide against transient focal cerebral ischemia via anti-apoptosis in rats. Neurol Res. 2012 Jan;34(1):32-7. PMID: 22196859.
Ho CY, Cheng YT, Chau CF, et al. Effect of diallyl sulfide on in vitro and in vivo Nrf2-mediated pulmonic antioxidant enzyme expression via activation ERK/p38 signaling pathway. J Agric Food Chem. 2012 Jan 11;60(1):100-7. PMID: 22118872.
