Rocuroniumisanaminosteroidthatexhibitsanestheticactivity,inducingrelaxationofskeletalmuscle.Rocuroniumisanon-depolarizingneuromuscularjunction(NMJ)blockerthatinhibitspost-synapticnicotinicacetylcholinereceptors(nAChRs);italsoinhibitsM2/3muscarinicacetylcholinereceptors(mAChRs).RocuroniumhasarapidonsetandcanbeadmiNISTeredwithaspecificantagonistthatterminatesitsaction.
| CasNo. | 119302-91-9 |
|---|---|
| Purity | ≥98% |
| Formula | C32H53BrN2O4 |
| FormulaWt. | 609.68 |
| IUPACName | [(2S,3S,5S,8R,9S,10S,13S,14S,16S,17R)-3-hydroxy-10,13-dimethyl-2-morpholin-4-yl-16-(1-prop-2-enylpyrrolidin-1-ium-1-yl)-2,3,4,5,6,7,8,9,11,12,14,15,16,17-tetradecahydro-1H-cyclopenta[a]phenanthren-17-yl]acetate;bromide |
| MeltingPoint | 162-164°C |
| Solubility | Water |
| Appearance | Whitetooffwhitepowder |
| StoreTemp | Ambient |
|---|---|
| ShipTemp | Ambient |
| MSDS | R5611MSDSPDF |
|---|---|
| InfoSheet | R5611InfoSheetPDF |
PapeA,KertschoH,SteinP,etal.Neuromuscularblockadewithrocuroniumbromideincreasesthetoleranceofacutenormovolemicanemiainanesthetizedpigs.EurSurgRes.2012;48(1):16-25.PMID:22189343.
BowmanWC.Neuromuscularblock.BrJPharmacol.2006Jan;147Suppl1:S277-86.PMID:16402115.
HouVY,HirshmanCA,EmalaCW.NeuromuscularrelaxantsasantagonistsforM2andM3muscarinicreceptors.Anesthesiology.1998Mar;88(3):744-50.PMID:9523819.
