RopiniroleisanindolineagoNISTatD2/3receptorsthatisclinicallyusedtotreatrestlesslegsyndromeandParkinson’sdisease.RopinirolepreventsdopaminergicneurondamageandMPTP-inducedchangesinmotorcoordinationandbalanceinanimalmodels,exhibitingneuroprotectivebenefit.Ropinirolealsodisplaysantidepressantactivity,decreasingimmobilitytimeintheforcedswimtest.
| CasNo. | 91374-20-8 |
|---|---|
| Purity | ≥99% |
| Formula | C16H24N2O•HCl |
| FormulaWt. | 296.84 |
| ChemicalName | 4-[2-(Dipropylamino)-ethyl]-1,3-dihydro-2H-indol-2-onehydrochloride |
| IUPACName | 4-[2-(dipropylamino)ethyl]-1,3-dihydroindol-2-one;hydrochloride |
| Synonym | SKF-101468A |
| MeltingPoint | 241-243°C |
| Solubility | Solubleinwater. |
| Appearance | LightYellowPowder |
| StoreTemp | 4°C |
|---|---|
| ShipTemp | Ambient |
| MSDS | R5661MSDSPDF |
|---|---|
| InfoSheet | R5661InfoSheetPDF |
ParkG,ParkYJ,YangHO,etal.Ropiniroleprotectsagainst1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine(MPTP)-inducedneurotoxicityinmiceviaanti-apoptoticmechanism.PharmacolBiochemBehav.2013Mar;104:163-8.PMID:23369986.
Ferini-StrambiL.Treatmentoptionsforrestlesslegssyndrome.ExpertOpinPharmacother.2009Mar;10(4):545-54.PMID:19284359.
DhirA,KulkarniSK.Involvementofdopamine(DA)/SEROtonin(5-HT)/sigma(sigma)receptormodulationinmediatingtheantidepressantactionofropinirolehydrochloride,aD2/D3dopaminereceptoragonist.BrainResBull.2007Sep14;74(1-3):58-65.PMID:17683790.
