SulpirideisanantipsychoticthatfunctionsasanantagoNISTatD2/3receptorsandalsoupregulatesandactivatestheGHBreceptor.Invivo,sulpirideamelioratesincreasedimpulsivityandattentionalimpairmentinPFC-lesionedmodelsofschizophrenia.Additionally,becausedopamineinhibitsprolactinrelease,sulpiride’sinhibitionofdopamineresultsinincreasedconcentrationsofprolactinaswellasmelanocyte-stimulatinghormone.
| CasNo. | 23672-07-3 |
|---|---|
| Purity | ≥99% |
| Formula | C15H23N3O4S |
| FormulaWt. | 341.43 |
| IUPACName | N-[[(2S)-1-ethylpyrrolidin-2-yl]methyl]-2-methoxy-5-sulfamoylbenzamide |
| MeltingPoint | 178-180°C |
| Appearance | Whitetooffwhitepowder |
| StoreTemp | Ambient |
|---|---|
| ShipTemp | Ambient |
| InfoSheet | S8345InfoSheetPDF |
|---|
ValenciaNA,ThompsonDLJr,MitchamPB.Changesinplasmamelanocyte-stimulatinghormone,ACTH,prolactin,GH,LH,FSH,andthyroid-stimulatinghormoneinresponsetoinjectionofsulpiride,thyrotropin-releasinghormone,orvehicleininsulin-sensitiveand-insensitivemares.DomestAnimEndocrinol.2013May;44(4):204-12.PMID:23571008.
PezzeMA,DalleyJW,RobbinsTW.Remediationofattentionaldysfunctioninratswithlesionsofthemedialprefrontalcortexbyintra-accumbensadministrationofthedopamineD(2/3)receptorantagonistsulpiride.Psychopharmacology(Berl).2009Jan;202(1-3):307-13.PMID:18985321.
RatomponirinaC,GobailleS,HodéY,etal.Sulpiride,butnothaloperidol,up-regulatesgamma-hydroxybutyratereceptorsinvivoandinculturedcells.EurJPharmacol.1998Apr10;346(2-3):331-7.PMID:9862377.
