S1RAactsasanantagoNISTatσ1receptors,exhibitinganalgesicandantinociceptiveproperties.S1RAreversesmechanicalandthermalpainsensitivityinanimalmodelsofinflammatorypain.Inmodelsofneuropathicpain,thiscompounddecreasesformalin-inducedglutamatereleaseandincreaseslevelsofnorepinephrine.
| CasNo. | 878141-96-9 |
|---|---|
| Purity | ≥99% |
| Formula | C20H23N3O2 |
| FormulaWt. | 337.42 |
| IUPACName | 4-(2-{[5-Methyl-1-(2-naphthyl)-1H-pyrazol-3-yl]oxy}ethyl)morpholine |
| Synonym | E52862,4-Morpholine |
| StoreTemp | -20°C |
|---|---|
| ShipTemp | Ambient |
| InfoSheet | S3368InfoSheetPDF |
|---|
GrisG,MerlosM,VelaJM,etal.S1RA,aselectivesigma-1receptorantagonist,inhibitsinflammatorypaininthecarrageenanandcompleteFreund"sadjuvantmodelsinmice.BehavPharmacol.2014Jun;25(3):226-35.PMID:24776490.
Vidal-TorresA,Fernández-PastorB,CarcellerA,etal.Effectsoftheselectivesigma-1receptorantagonistS1RAonformalin-inducedpainbehaviorandneurotransmitterreleaseinthespinalcordinrats.JNeuRochem.2014May;129(3):484-94.PMID:24384038.
BuraAS,GueganT,ZamanilloD,etal.Operantself-administrationofasigmaligandimprovesnociceptiveandemotionalmanifestationsofneuropathicpain.EurJPain.2013Jul;17(6):832-43.PMID:23172791.
