Phenylbutazoneisanon-steroidalanti-inflammatorydrug(NSAID)thatinhibitsCOX-1andCOX-2activity;itisnolongerusedinhumans,butwaspreviouslyusedtotreatinflammatorydiseasessuchasarthritisandgout.Phenylbutazoneexhibitsanti-inflammatory,analgesic,antipyretic,andantioxidativeactivities.Invivo,phenylbutazonedecreasesedema;inseparatecellularmodels,itinhibitsactivityofmyeloperoxidase.
| CasNo. | 50-33-9 |
|---|---|
| Purity | ≥98% |
| Formula | C19H20N2O2 |
| FormulaWt. | 308.37 |
| ChemicalName | 4-Butyl-1,2-diphenyl-3,5-pyrazolidinedione |
| IUPACName | 4-butyl-1,2-diphenylpyrazolidine-3,5-dione |
| Synonym | Ambene;Artrizin;ButADIon;Butoz;Equipalazone;Fenibutol;Intrabutazone;Phenyzene;Tevcodyne;Uzone |
| MeltingPoint | 105°C |
| Solubility | Solubleinwater. |
| Appearance | Whitetooffwhitepowder |
| StoreTemp | Ambient |
|---|---|
| ShipTemp | Ambient |
| InfoSheet | P2810InfoSheetPDF |
|---|
CusanC,AltinierG,SosaS,etal.Anti-inflammatoryandanti-oxidantactivityofanewclassofphenyl-pyrazolonederivatives.CurrDrugDiscovTechnol.2006Mar;3(1):67-73.PMID:16712464.
KettleAJ,WinterbournCC.Mechanismofinhibitionofmyeloperoxidasebyanti-inflammatorydrugs.BiochemPharmacol.1991May15;41(10):1485-92.PMID:1850278.
