Description
Pimecrolimusisacalcineurininhibitorthatexhibitsimmunosuppressive,anti-inflammatory,andantinociceptiveactivities.PimecrolimuspreventscalcineurinfromdephosphorylatingnuclearfactorofactivatedTcells(NF-AT),inhibitingTcellsignaling;thisinhibitionofTcellsignalingalsopreventsreleaseofpro-inflammatorycytokines.Pimecrolimusisclinicallyusedtotreatinflammatoryskindiseasessuchascutaneouslupuserythematosusandcontactdermatitis.Thiscompoundalsodisplayssomeantinociceptivepropertiesandmaydesensitizetransientreceptorpotentialvanilloidreceptor1(TRPV1)channelsinskinsensoryneurons.
References
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