Piroxicamisanon-steroidalanti-inflammatorydrug(NSAID)thatexhibitsanti-inflammatory,analgesic,antipyretic,neuroprotective,anticancer,andchemopreventiveactivities.PiroxicaminhibitsCOX-1andCOX-2.Cu(II)complexesofpiroxicambindGCsequencesofDNA.Inanimalmodels,thiscompounddecreasesdevelopmentofpolypsandcolorectalcancer.IncellularmodelsofParkinson’sdisease,piroxicaminhibitsMPP+-induceddecreasesinphosphorylatedAktandneurodegeneration.
| CasNo. | 36322-90-4 |
|---|---|
| Purity | ≥98% |
| Formula | C15H13N3O4S |
| FormulaWt. | 331.35 |
| ChemicalName | 4-Hydroxy-2-methyl-N-(2-pyridyl)-2H-1,2-benzothiazine-3-carboxamide-1,1-dioxide |
| IUPACName | 4-hydroxy-2-methyl-1,1-dioxo-N-pyridin-2-yl-1λ6,2-benzothiazine-3-carboxamide |
| Synonym | Feldene;Piroftal;Roxicam |
| MeltingPoint | 198-200°C |
| Solubility | Insolubleinwater.Solubleinacetonitrile. |
| Appearance | Off-WhiteCrystalPowder |
| StoreTemp | Ambient |
|---|---|
| ShipTemp | Ambient |
| InfoSheet | P3269InfoSheetPDF |
|---|---|
| Brochures | NSAIDFlyer |
ChakrabortyS,BoseM,SarkarM.SpectroscopicstudiesofthebindingofCu(II)complexesofoxicamNSAIDstoalternatingG-CandhomopolymericG-Csequences.SpectrochimActaAMolBiomolSpectrosc.2014Mar25;122:690-7.PMID:24345609.
BarkinRL.TopicalNonsteroidalAnti-InflammatoryDrugs:TheImportanceofDrug,Delivery,andTherapeuticOutcome.AmJTher.2012Feb22.[Epubaheadofprint].PMID:22367354.
TasakiY,YamamotoJ,OmuraT,etal.Oxicamstructureinnon-steroidalanti-inflammatorydrugsisessentialtoexhibitAkt-mediatedneuroprotectionagainst1-methyl-4-phenylpyridinium-inducedcytotoxicity.EurJPharmacol.2012Feb15;676(1-3):57-63.PMID:22182582.
QiuZF,MaruyamaK,SunayamaK,etal.Piroxicam-inducedregressionofintestinaladenomatouspolypsinAPC(delta474)mice.JInvestSurg.2003Mar-Apr;16(2):71-81.PMID:12746190.
