PR-619inhibitsdeubiquitinatingenzymes(DUBs)andisusedtostudytheroleofubiquitinationinneurodegenerativediseases.Thiscompounddisplaysanti-inflammatoryactivity,inhibitingsecretionofIL-1βinmacrophages.Inoligodendrocytes,PR-619activatesautophagyandaggrosomeformation,stABIlizesthemicrotubulenetwork,andinducesstressresponses.
| CasNo. | 2645-32-1 |
|---|---|
| Purity | ≥98% |
| Formula | C7H5N5S2 |
| FormulaWt. | 223.27 |
| IUPACName | 2,6-Diamino-3,5-pyridinediylbis(thiocyanate) |
| StoreTemp | -20°C |
|---|---|
| ShipTemp | Ambient |
| InfoSheet | P7000InfoSheetPDF |
|---|
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SeiberlichV,BorchertJ,ZhukarevaV,etal.InhibitionofproteindeubiquitinationbyPR-619activatestheautophagicpathwayinOLN-t40oligodendroglialcells.CellBiochemBiophys.2013Sep;67(1):149-60.PMID:23686611.
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