Pramipexole is an agonist at D2/3 receptors that is clinically used to treat symptoms of Parkinson’s disease. Pramipexole exhibits neuroprotective and antidepressant activities. In animal models, pramipexole decreases immobility time in the forced swim test. In vitro, this compound inhibits LPS-induced degeneration of neurons and also inhibits phosphorylation of α-synuclein.
| Cas No. | 191217-81-9 |
|---|---|
| Purity | ≥98% |
| Formula | C10H17N3S • 2HCl • H2O |
| Formula Wt. | 302.26 |
| Chemical Name | (S)-2-amino-4,5,6,7-tetrahydro-6-(propylamino)benzothiazole dihydrochloride |
| IUPAC Name | (6S)-6-N-propyl-4,5,6,7-tetrahydro-1,3-benzothiazole-2,6-diamine;hydrate;dihydrochloride |
| Melting Point | 288-290°C |
| Appearance | White to off white powder |
| Store Temp | Ambient |
|---|---|
| Ship Temp | Ambient |
| Info Sheet | P6901 Info Sheet PDF |
|---|
Chau KY, Cooper JM, Schapira AH. Pramipexole reduces phosphorylation of α-synuclein at serine-129. J Mol Neurosci. 2013 Oct;51(2):573-80. PMID: 23681749.
Kitagawa K, Kitamura Y, Miyazaki T, et al. Effects of pramipexole on the duration of immobility during the forced swim test in normal and ACTH-treated rats. Naunyn Schmiedebergs Arch Pharmacol. 2009 Jul;380(1):59-66. PMID: 19274453.
Iravani MM, Sadeghian M, Leung CC, et al. Continuous subcutaneous infusion of pramipexole protects against lipopolysaccharide-induced dopaminergic cell death without affecting the inflammatory response. Exp Neurol. 2008 Aug;212(2):522-31. PMID: 18571649.
Zarate CA Jr, Payne JL, Singh J, et al. Pramipexole for bipolar II depression: a placebo-controlled proof of concept study. Biol Psychiatry. 2004 Jul 1;56(1):54-60. PMID: 15219473.
Ling ZD, Robie HC, Tong CW, et al. Both the antioxidant and D3 agonist actions of pramipexole mediate its neuroprotective actions in mesencephalic cultures. J Pharmacol Exp Ther. 1999 Apr;289(1):202-10. PMID: 10087005.
Ono K, Takasaki J, Takahashi R, et al. Effects of antiparkinsonian agents on beta-amyloid and alpha-synuclein oligomer formation in vitro. J Neurosci Res. 2013 Oct;91(10):1371-1381. PMID: 23913715.
