Description
Prednisoneisasyntheticcorticosteroid/glucocorticoidthatexhibitsnoBIOLOGicalactivityuntilconvertedtoitsactivemetabolite,prednisolone.Onceconverted,thiscompoundexhibitsanti-inflammatory,immunosuppressive,anti-allergic,neuroprotective,andanticancerchemotherapeuticactivities.PrednisoneisonecomponentoftheCHOPchemotherapeuticcocktailthatisclinicallyusedtotreatleukemiasandlymphomas;inanimalmodelsofsubarachnoidhemorrhage,CHOPinhibitsneuronalapoptosis.PrednisonealsoinhibitsexpressionofIL-6andisclinicallyusedtotreatrheumatoidarthritis.
References
HoySM.Bendamustine:areviewofitsuseinthemanagementofchroniclymphocyticleukaemia,rituximab-refractoryindolentnon-Hodgkin"slymphomaandmultiplemyeloma.Drugs.2012Oct1;72(14):1929-50.PMID:22950536.
ClarkeL,KirwanJ.Efficacy,safetyandmechanismofactionofmodified-releaseprednisoneinrheumatoidarthritis.TherAdvMusculoskeletDis.2012Jun;4(3):159-66.PMID:22850902.
HeZ,OstrowskiRP,SunX,etal.CHOPsilencingreducesacutebraininjuryintheratmodelofsubarachnoidhemorrhage.Stroke.2012Feb;43(2):484-90.PMID:22180248.
MannsMP,StrassburgCP.Therapeuticstrategiesforautoimmunehepatitis.DigDis.2011;29(4):411-5.PMID:21894012.