Description
RamelteonisamelatoninMT1/2receptoragoNISTusedclinicallytotreatinsomnia.Ramelteondisplayshypnoticactivityandmaybeimmunostimulatoryaswell.Inanimalmodels,ramelteondecreaseswakefulnessandincreasesslow-waveandrapideyemovement(REM)sleep.
RamelteonisamelatoninMT1/2receptoragoNISTusedclinicallytotreatinsomnia.Ramelteondisplayshypnoticactivityandmaybeimmunostimulatoryaswell.Inanimalmodels,ramelteondecreaseswakefulnessandincreasesslow-waveandrapideyemovement(REM)sleep.
CasNo. | 196597-26-9 |
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Purity | ≥98% |
Formula | C16H21NO2 |
FormulaWt. | 259.34 |
ChemicalName | (S)-N-[2-(1,6,7,8-tetrahydro-2H-indeno-[5,4-b]furan-8-yl)ethyl]propionamide |
IUPACName | N-[2-[(8S)-2,6,7,8-tetrahydro-1H-cyclopenta[e][1]benzofuran-8-yl]ethyl]propanamide |
MeltingPoint | 113-116°C |
Solubility | Solubleinwater(<1.2 mg/ml),="" ethanol="" (≥50="" mg/ml),="" dmso="" (≥50="" mg/ml),="" dmf,="" and="">1.2> |
Appearance | Whitetooffwhitepowder |
StoreTemp | Ambient |
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ShipTemp | Ambient |
InfoSheet | R0348InfoSheetPDF |
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FourmanLT,RobertMeyerB.Autoimmunehepatitisinassociationwithramelteon.JClinGastroenterol.2013Aug;47(7):651-4.PMID:23632362.
ZammitGK.Ramelteon:anovelhypnoticindicatedforthetreatmentofinsomnia.Psychiatry(Edgmont).2007Sep;4(9):36-42.PMID:20532119.
MiyamotoM,NishikawaH,DokenY,etal.Thesleep-promotingactionoframelteon(TAK-375)infreelymovingcats.Sleep.2004Nov1;27(7):1319-25.PMID:15586784.