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当前位置: 首页 > 产品中心 > clinical_research > LKT/RASAGILINE MESYLATE/R0272/25 mg
商品详细LKT/RASAGILINE MESYLATE/R0272/25 mg
LKT/RASAGILINE MESYLATE/R0272/25 mg
LKT/RASAGILINE MESYLATE/R0272/25 mg
商品编号: R0272-25mg
品牌: lktlabs
市场价: ¥1660.00
美元价: 996.00
产地: 美国(厂家直采)
公司:
产品分类: 临床研究
公司分类: clinical_research
联系Q Q: 3392242852
电话号码: 4000-520-616
电子邮箱: info@ebiomall.com
商品介绍
  • Description
  • ProductInfo
  • ShippingandStorage
  • Downloads
  • References

Description

RasagilineisaninhibitorofmonoamineoxidaseB(MAO-B)thatisusedtotreatParkinson’sdisease.RasagilinemayalsoexhibiteffectsonMAO-A,asactionsonthatenzymearelikelyresponsIBLefortheABIlityofrasagilinetoincreaselevelsofBcl-2,glialcellline-derivedneurotrophicfactor(GDNF),andbrain-derivedneurotrophicfactor(BDNF).Rasagilinealsodisplaysneuroprotectiveactivity,inhibitingmitochondrialmembranepermeability,preventingcaspase-andmitochondria-mediatedapoptosis.

ProductInfo

CasNo.

161735-79-1

Purity

≥98%

Formula

C12H13N•CH3SO3H

FormulaWt.

267.34

ChemicalName

(R)-N-2-Propynyl-1-indanaminemesylate

IUPACName

(1R)-N-prop-2-ynyl-2,3-dihydro-1H-inden-1-amine

MeltingPoint

154.1~155.5°C

Solubility

Freelysolubleinwater,methanolandethanol.

Appearance

Whitetooffwhitepowder

ShippingandStorage

StoreTemp

Ambient

ShipTemp

Ambient

Downloads

MSDS

R0272MSDSPDF

InfoSheet

R0272InfoSheetPDF

References

NaoiM,MaruyamaW,Inaba-HasegawaK.Revelationintheneuroprotectivefunctionsofrasagilineandselegiline:theinductionofdistinctgenesbydifferentmechanisms.ExpertRevNeurother.2013Jun;13(6):671-84.PMID:23739004.

NaoiM,MaruyamaW,YiH.RasagilinepreventsapoptosisinducedbyPK11195,aligandoftheoutermembranetranslocatorprotein(18kDa),inSH-SY5Ycellsthroughsuppressionofcytochromecreleasefrommitochondria.JNeuralTransm.2013Nov;120(11):1539-51.PMID:23681678.

Inaba-HasegawaK,AkaoY,MaruyamaW,etal.TypeAmonoamineoxidaseisassociatedwithinductionofneuroprotectiveBcl-2byrasagiline,aninhibitoroftypeBmonoamineoxidase.JNeuralTransm.2012Apr;119(4):405-14.PMID:22065207.

WeinrebO,AmitT,Bar-AmO,etal.InductionofneurotrophicfactorsGDNFandBDNFassociatedwiththemechanismofneurorescueactionofrasagilineandladostigil:newinsightsandimplicationsfortherapy.AnnNYAcadSci.2007Dec;1122:155-68.PMID:18077571.

品牌介绍
LKT Labs LKT Labs 是一家专注于防癌抗癌特殊化学品研究和开发的公司。主要提供:癌症药物、药物发现试剂盒、天然产物、广泛的生命科学研究试剂、定制合成。美国LKT Labs 是1988年在美国成立的,为全球提供先端的药物研发试剂、试剂盒、委托合成,并为药物生产企业提供原料,最近几年在农药、水产养殖业有很大程度的开发。在LKT Labs 可以找到在其他地方找不到的产品。 试剂