Description
RasagilineisaninhibitorofmonoamineoxidaseB(MAO-B)thatisusedtotreatParkinson’sdisease.RasagilinemayalsoexhibiteffectsonMAO-A,asactionsonthatenzymearelikelyresponsIBLefortheABIlityofrasagilinetoincreaselevelsofBcl-2,glialcellline-derivedneurotrophicfactor(GDNF),andbrain-derivedneurotrophicfactor(BDNF).Rasagilinealsodisplaysneuroprotectiveactivity,inhibitingmitochondrialmembranepermeability,preventingcaspase-andmitochondria-mediatedapoptosis.
References
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NaoiM,MaruyamaW,YiH.RasagilinepreventsapoptosisinducedbyPK11195,aligandoftheoutermembranetranslocatorprotein(18kDa),inSH-SY5Ycellsthroughsuppressionofcytochromecreleasefrommitochondria.JNeuralTransm.2013Nov;120(11):1539-51.PMID:23681678.
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