RG-108isaninhibitorofDNAmethyltransferases(DNMTs)thatexhibitsantidepressant,neuromodulatory,anticancer,andantiepilepticactivities.RG-108attenuatesstress-inducedbehavioraladaptationsinanimalmodelsandinhibitspersistentepileptiformactivity.RG-108alsoincreasesTERTexpression.Inprostatecancercells,thiscompoundinducesapoptosisandinhibitscellgrowth.
| CasNo. | 48208-26-0 |
|---|---|
| Purity | ≥98% |
| Formula | C19H14N2O4 |
| FormulaWt. | 334.33 |
| IUPACName | (2S)-2-(1,3-Dioxo-1,3-dihydro-2H-isoindol-2-yl)-3-(1H-indol-3-yl)propanoicacid |
| StoreTemp | -20°C |
|---|---|
| ShipTemp | Ambient |
| InfoSheet | R2400InfoSheetPDF |
|---|
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OhYS,JeongSG,ChoGW.Anti-senescenceeffectsofDNAmethyltransferaseinhibitorRG108inhumanbonemarrowmesenchymalstromalcells.BiotechnolApplBiochem.2015May8.[Epubaheadofprint].PMID:25952632.
GraçaI,SousaEJ,BaptistaT,etal.Anti-tumoraleffectofthenon-nucleosideDNMTinhibitorRG108inhumanprostatecancercells.CurrPharmDes.2014;20(11):1803-11.PMID:23888969.
MachnesZM,HuangTC,ChangPK,etal.DNAmethylationmediatespersistentepileptiformactivityinvitroandinvivo.PLoSOne.2013Oct2;8(10):e76299.PMID:24098468.
