CKS-17 is a synthetic peptide with a sequence homologous to endogenous retroviral transmembrane envelope proteins; it exhibits immunosuppressive activity in vitro and in vivo. In one study, CKS-17 inhibits production of IL-12, IL-2, TNF-α, and IFN-γ, increases levels of cAMP and IL-10, and activates ERK1/2, MEK, PKD, PLC-γ, and c-Raf; this results in an inhibition of the Th1-centric immune response.
| Cas No. | 99273-04-8 |
|---|---|
| Purity | ≥95% |
| Formula | C87H148N26O24 |
| Formula Wt. | 1942.31 |
| Store Temp | -20°C |
|---|---|
| Ship Temp | Ambient |
| Info Sheet | C4274 Info Sheet PDF |
|---|
Haraguchi S, Good RA, Day-Good NK. A potent immunosuppressive retroviral peptide: cytokine patterns and signaling pathways. Immunol Res. 2008;41(1):46-55. PMID: 18506644.
Fan Tx, Day NK, Luangwedchakarn V, et al. The phosphorylation of phospholipase C-gamma1, Raf-1, MEK, and ERK1/2 induced by a conserved retroviral peptide. Peptides. 2005 Nov;26(11):2165-74. PMID: 15978701.
Takahashi A, Day NK, Luangwedchakarn V, et al. A retroviral-derived immunosuppressive peptide activates mitogen-activated protein kinases. J Immunol. 2001 Jun 1;166(11):6771-5. PMID: 11359835.
Kabeya H, Ohashi K, Sugimoto C, et al. Bovine leukaemia virus envelope peptides cause immunomodulation in BALB/c mice. Vet Immunol Immunopathol. 1999 Mar 29;68(1):39-48. PMID: 10231950.
