CyclosporinAisacyclicpeptidethatexhibitsimmunosuppressiveactivity.CyclosporinAisclinicallyusedtopreventrejectioninorgantransplantsandtotreatorpreventgraft-versus-hostdisease(GvHD).CyclosporinAbindscyclophilin,inhibitingcalcineurinanddecreasinglevelsofIL-2andactivatedTcells.CyclosporinAalsoshowsbenefitinthetreatmentoftraumaticbraininjury.
| CasNo. | 59865-13-3 |
|---|---|
| Purity | ≥98% |
| Formula | C62H111N11O12 |
| FormulaWt. | 1202.61 |
| IUPACName | (3S,6S,9S,12R,15S,18S,21S,24S,30S,33S)-30-ethyl-33-[(E,1R,2R)-1-hydroxy-2-methylhex-4-enyl]-1,4,7,10,12,15,19,25,28-nonamethyl-6,9,18,24-tetrakis(2-methylpropyl)-3,21-di(propan-2-yl)-1,4,7,10,13,16,19,22,25,28,31-undecazacyclotritriacontane-2,5,8,11,14,17,20,23,26,29,32-undecone |
| Synonym | Cyclosporine;Ciclosporin;Sandimmun;Neoral |
| MeltingPoint | 148-151°C |
| Solubility | Solubleinmethanol,ethanol,acetone,etherorchloroform.Veryslightlysolubleinwater. |
| Appearance | WhiteCrystalPowder |
| StoreTemp | Ambient |
|---|---|
| ShipTemp | Ambient |
| MSDS | C9611MSDSPDF |
|---|---|
| InfoSheet | C9611InfoSheetPDF |
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HandschumacherRE,HardingMW,RiceJ,etal.Cyclophilin:aspecificcytosolicbindingproteinforcyclosporinA.Science.1984Nov2;226(4674):544-7.PMID:6238408.
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