Deslorelinisagonadotropin-releasinghormone(GnRH)agoNISTthatisusedtocontrolfertilityandtreatbenignprostatichyperplasia(BPH)inveterinarymedicine.DeslorelindecreasesexpressionofGnRHreceptorsandlevelsoftestosterone,decreasingthevolumeofthetestesandprostateinmanymaleanimalmodels.Inmaleanimals,deslorelinisusedtoinstillsterility.Infemaleanimals,thispeptideisusedtoinduceestrous.
| CasNo. | 57773-65-6 |
|---|---|
| Purity | ≥95% |
| Formula | C64H83N17O12 |
| FormulaWt. | 1282.47 |
| IUPACName | N-[1-[[1-[[1-[[1-[[1-[[1-[[5-(diaminomethylideneamino)-1-[2-(ethylcarbamoyl)pyrrolidin-1-yl]-1-oxopentan-2-yl]amino]-4-methyl-1-oxopentan-2-yl]amino]-3-(1H-indol-3-yl)-1-oxopropan-2-yl]amino]-3-(4-hydroxyphenyl)-1-oxopropan-2-yl]amino]-3-hydroxy-1-oxopropan-2-yl]amino]-3-(1H-indol-3-yl)-1-oxopropan-2-yl]amino]-3-(1H-imidazol-5-yl)-1-oxopropan-2-yl]-5-oxopyrrolidine-2-carboxamide |
| StoreTemp | -20°C |
|---|---|
| ShipTemp | Ambient |
| InfoSheet | D1775InfoSheetPDF |
|---|
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Goericke-PeschS,GeorgievP,FasulkovI,etal.Basaltestosteroneconcentrationsaftertheapplicationofaslow-releaseGnRHagonistimplantareassociatedwithalossofresponsetobuserelin,ashort-termGnRHagonist,inthetomcat.Theriogenology.2013Jul1;80(1):65-9.PMID:23622940.
PoliscaA,OrlandiR,TroisiA,etal.ClinicalefficacyoftheGnRHagonist(deslorelin)indogsaffectedbybenignprostatichyperplasiaandevaluationofprostaticbloodflowbyDopplerultrasound.ReprodDomestAnim.2013Aug;48(4):673-80.PMID:23320475.
WolfT,MeyerH,KutzlerM.Littersizeresponsetooestrousinductionwithdeslorelin(Ovuplant®)indogs.ReprodDomestAnim.2012Dec;47Suppl6:387-8.PMID:23279545.
