Endomorphin-1isanendogenousagoNISTatμ-opioidreceptors(μORs)inthespinalcord;itexhibitsantinociceptive/analgesic,immunosuppressive,andpro-angiogenicactivities.Endomorphin-1increasespainthresholdsinanimalmodelsofthermalpainandinhibitstheformationofantibodiesinothercellularmodels.InHUVECs,thispeptidestimulatesproliferation,migration,adhesion,andtubeformation.
| CasNo. | 189388-22-5 |
|---|---|
| Purity | ≥95% |
| Formula | C34H38N6O5 |
| FormulaWt. | 610.72 |
| IUPACName | (2S)-1-[(2S)-2-amino-3-(4-hydroxyphenyl)propanoyl]-N-[(2S)-1-[[(2S)-1-amino-1-oxo-3-phenylpropan-2-yl]amino]-3-(1H-indol-3-yl)-1-oxopropan-2-yl]pyrrolidine-2-carboxamide |
| StoreTemp | -20°C |
|---|---|
| ShipTemp | Ambient |
| InfoSheet | E5210InfoSheetPDF |
|---|
DaiX,SongHJ,CuiSG,etal.Thestimulativeeffectsofendogenousopioidsonendothelialcellproliferation,migrationandangiogenesisinvitro.EurJPharmacol.2010Feb25;628(1-3):42-50.PMID:19932695.
AntonB,LeffP,CalvaJC,etal.Endomorphin1andendomorphin2suppressinvitroantibodyformationatultra-lowconcentrations:anti-peptideantibodiesbutnotopioidantagonistsblocktheactivity.BrainBehavImmun.2008Aug;22(6):824-32.PMID:18374539.
