Endothelin-1isanendogenouspeptideagoNISTatendothelinAandB(ET-A/B)receptorsthatexhibitsanti-angiogenicandvasoconstrictiveactivities.Endothelin-1decreasestubeformationandPPARγexpressioninpulmonaryarteryendothelialcells.ThispeptidealsoincreasesexpressionofIL-18inosteoblasts,inducingproliferation.
| Purity | ≥95% |
|---|---|
| Formula | C109H159N25O32S5 |
| FormulaWt. | 2491.95 |
| Appearance | Whitetooffwhitepowder |
| StoreTemp | -20°C |
|---|---|
| ShipTemp | Ambient |
| MSDS | E5219MSDSPDF |
|---|---|
| InfoSheet | E5219InfoSheetPDF |
ZhongX,WangH,HuangS.Endothelin-1inducesinterleukin-18expressioninhumanosteoblasts.ArchOralBiol.2014Mar;59(3):289-96.PMID:24581851.
OsmondJM,GonzalezBoscLV,WalkerBR,etal.Endothelin-1-inducedvasoconstrictiondoesnotrequireintracellularCa2+wavesinarteriesfromratsexposedtointermittenthypoxia.AmJPhysiolHeartCircPhysiol.2014Mar;306(5):H667-73.PMID:24414066.
WolfD,TsengN,SeedorfG,etal.Endothelin-1decreasesendothelialPPARγsignalingandimpairsangiogenesisafterchronicintrauterinepulmonaryhypertension.AmJPhysiolLungCellMolPhysiol.2014Feb;306(4):L361-71.PMID:24337925.
