Endothelin-2isanendogenouspeptideagoNISTatendothelinAandB(ET-A/B)receptorsthatexhibitsanti-angiogenicandvasoconstrictiveactivities.Endothelin-2inhibitsendothelialcellmigrationandinvasion,suppressingvasculardevelopmentintheretina.Inarteries,thispeptideinducesvasoconstrictioninaPLC/ROCK-dependentmanner.Additionally,endothelin-2promotesmyelinationinanimalmodels.
| CasNo. | 123562-20-9 |
|---|---|
| Purity | ≥95% |
| Formula | C115H160N26O32S4 |
| FormulaWt. | 2546.97 |
| Appearance | Whitetooffwhitepowder |
| StoreTemp | -20°C |
|---|---|
| ShipTemp | Ambient |
| MSDS | E5221MSDSPDF |
|---|---|
| InfoSheet | E5221InfoSheetPDF |
CompeerMG,JanssenGM,DeMeyJG.Endothelin-1andendothelin-2initiateandmaintaincontractileresponsesbydifferentmechanismsinratmesentericandcerebralarteries.BrJPharmacol.2013Nov;170(6):1199-209.PMID:23941276.
RattnerA,YuH,WilliamsJ,etal.Endothelin-2signalingintheneuralretinapromotestheendothelialtipcellstateandinhibitsangiogenesis.ProcNatlAcadSciUSA.2013Oct1;110(40):E3830-9.PMID:24043815.
YuenTJ,JohnsonKR,MironVE,etal.Identificationofendothelin2asaninflammatoryfactorthatpromotescentralnervoussystemremyelination.Brain.2013Apr;136(Pt4):1035-47.PMID:23518706.
