Endothelin-3isanendogenouspeptideagoNISTatendothelinB(ET-B)receptorsthatexhibitsanti-inflammatory,neuromodulatory,andpro-angiogenicactivities.Inanimalmodels,endothelin-3inhibitsplatelet-activatingfactor-inducededema.Inothermodels,thispeptidedecreasestyrosinehydroxylaseactivityinanNO/cGMP/PKG-dependentmanner,suppressinghypothalamicreleaseofnorepinephrine.Invitro,endothelin-3activatesET-Breceptors,increasingexpressionofVEGF,COX1/2,HIF-1α,andPGE2.
| CasNo. | 117399-93-6 |
|---|---|
| Purity | ≥95% |
| Formula | C121H168N26O33S4 |
| FormulaWt. | 2643.1 |
| Synonym | Ratendothelin-3 |
| StoreTemp | -20°C |
|---|---|
| ShipTemp | Ambient |
| MSDS | E5222MSDSPDF |
|---|---|
| InfoSheet | E5222InfoSheetPDF |
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