Enniatinsareagroupofmycotoxinsproducedbyseveralfungalspecies.Theyarecyclichexadepsipeptidesstructurallyrelatedtobeauvericin.Theymaybefoundascontaminantsinfoodcommodities,particularlyincerealgrains.EnniatinsarefoundtohaveavarietyofBIOLOGicalactivitiesincludinginsecticidal,antifungal,antibioticandcytotoxicproperties.Theyhavebeenshowntoinduceapoptosisinseveralhumancancercelllinesandaregaininginterestaspotentialanticancerdrugs.
| CasNo. | 2503-13-1 |
|---|---|
| Purity | ≥97% |
| Formula | C36H63N3O9 |
| FormulaWt. | 681.91 |
| ChemicalName | (3S,9S,12R,15S,18R)-9,15-bis[(2S)-butan-2-yl]-3-[(2R)-butan-2-yl]-4,10,16-trimethyl-6,12,18-tri(propan-2-yl)-1,7,13-trioxa-4,10,16-triazacyclooctadecane-2,5,8,11,14,17-hexone |
| IUPACName | (3S,6R,9S,12R,15S,18R)-3,9,15-Tri[(2S)-2-butanyl]-6,12,18-triisopropyl-4,10,16-trimethyl-1,7,13-trioxa-4,10,16-triazacyclooctadecane-2,5,8,11,14,17-hexone |
| Synonym | Fusafungine,cyclo[N(Me)Ile-D-OVal-N(Me)Ile-DL-OVal-N(Me)aIle-D-OVal] |
| MeltingPoint | 121-125°C |
| Solubility | Solubleinethanol,methanol,DMSO,DMF.Insolubleinwater. |
| Appearance | Whitepowder |
| StoreTemp | -20°C |
|---|---|
| ShipTemp | Ambient |
| InfoSheet | E537332InfoSheetPDF |
|---|
LiuzziVC,MirabelliV,CimmarustiMT,etal.EnniatinandbeauvericinbiosynthesisinFusariumspecies:productionprofilesandstructuraldeterminantprediction.Toxins(Basel).2017Feb;9(2):45.PMID:28125067.
GunterAB,HermansA,BosnichW,etal.ProteinengineeringofSaccharomycescerevisiaetransporterPdr5pidentifieskeyresiduesthatimpactFusariummycotoxinexportandresistancetoinhibition.Microbiologyopen.2016Dec;5(6):979-991.PMID:27263049.
NazariF,SulyokM,KobarfardF,etal.Evaluationofemergingmycotoxinsbeauvericin,enniatins,fusaproliferinandmoniliforminindomesticriceinIran.IranJPharmRes.2015Spring;14(2):505-512.PMID:25901158.
Dornetshuber-FleissR,HeilosD,MohrT,etal.ThenaturallybornfusariotoxinenniatinBandsorafenibexertsynergisticactivityagainstcervicalcancerinvitroandinvivo.BiochemPharmacol.2015Feb1;93(3):318-331.PMID:25557295.
