Fibrinogenγ-chaindodecapeptidebindsglycoproteinGPIIb/IIIaonplatelets,exhibitinghemostatic,pro-thromboticactivityandenhancingthrombusformation.Thispeptiderescuesthrombocytopenicrabbitsfromliverhemorrhageandisclinicallyusedasaplateletsubstitute.
| Purity | ≥98% |
|---|---|
| Formula | C50H80N18O16 |
| FormulaWt. | 1189.29 |
| Synonym | Fibrinogengamma-chaindodecapeptide,FibrinogenBindingInhibitorPeptide |
| Appearance | Whitepowder |
| StoreTemp | -20°C |
|---|---|
| ShipTemp | Ambient |
| MSDS | F3205MSDSPDF |
|---|---|
| InfoSheet | F3205InfoSheetPDF |
TokutomiK,TagawaT,KorenagaM,etal.ABIlityoffibrinogenγ-deriveddodecapeptideswithdifferentsequencestobindtoratplatelets.IntJPharm.2012Nov15;438(1-2):296-301.PMID:22985603.
NishikawaK,HagisawaK,KinoshitaM,etal.Fibrinogenγ-chainpeptide-coated,ADP-encapsulatedliposomesrescuethrombocytopenicrabbitsfromnon-compressIBLeliverhemorrhage.JThrombHaemost.2012Oct;10(10):2137-48.PMID:22905905.
OkamuraY,MaekawaI,TeramuraY,etal.Hemostaticeffectsofphospholipidvesiclescarryingfibrinogengammachaindodecapeptideinvitroandinvivo.BioconjugChem.2005Nov-Dec;16(6):1589-96.PMID:16287259.
