FibronectinCS-1peptidebindsα4β1integrin;itexhibitspro-metastaticandimmunomodulatoryactivities.FibronectinCS-1peptideisinvolvedinoralsquamouscellcarcinomapathogenesis,regulatingmigrationandinvasion.Thispeptidemayincreaseexpressionofmatrixmetalloproteinases(MMPs).Invitro,fibronectinCS-1peptidestimulatesproliferationofTcells.Inanimalmodelsofcerebralischemia/reperfusion,fibronectinCS-1peptidedecreasesleukocyteinfiltrationinlesionedareas,decreasinginfarctsize.
| Purity | ≥95% |
|---|---|
| Formula | C38H64N8O15 |
| FormulaWt. | 872.97 |
| Synonym | FibronectinCS1 |
| Solubility | Solubleinwater. |
| Appearance | Whitetooff-whitepowder |
| StoreTemp | -20°C |
|---|---|
| ShipTemp | Ambient |
| InfoSheet | F3207InfoSheetPDF |
|---|
KamarajanP,Garcia-PardoA,D"SilvaNJ,etal.TheCS1segmentoffibronectinisinvolvedinhumanOSCCpathogenesisbymediatingOSCCcellspreADIng,migration,andinvasion.BMCCancer.2010Jun25;10:330.PMID:20579373.
YakubenkoVP,LobbRR,PlowEF,etal.DifferentialinductionofgelatinaseB(MMP-9)andgelatinaseA(MMP-2)inTlymphocytesuponalpha(4)beta(1)-mediatedadhesiontoVCAM-1andtheCS-1peptideoffibronectin.ExpCellRes.2000Oct10;260(1):73-84.PMID:11010812.
LehnertK,PrintCG,YangY,etal.MAdCAM-1costimulatesTcellproliferationexclusivelythroughintegrinalpha4beta7,whereasVCAM-1andCS-1peptideusealpha4beta1:evidencefor"remote"costimulationandinductionofhyperresponsivenesstoB7molecules.EurJImmunol.1998Nov;28(11):3605-15.PMID:9842903.
YanakaK,CamarataPJ,SpellmanSR,etal.Neuronalprotectionfromcerebralischemiabysyntheticfibronectinpeptidestoleukocyteadhesionmolecules.JCerebBloodFlowMetab.1996Nov;16(6):1120-5.PMID:8898683.
