Description
Pituitaryadenylatecyclase-activatingpolypeptide(PACAP)stimulatescAMPproductionintheanteriorpituitary.PACAPandPACAP-relatedpeptide(PRP)regulateimmunefunctionanddisplayincreasesinexpressionwhenhostsarechallengedwithbacterialpathogens.PACAPandPRPalsocontrolexpressionofreproductivehormonessuchasfollicle-stimulatinghormone(FSH)andluteinizinghormone(LH).Additionally,PACAPandPRPbindthePAC1receptorandVPAC1/2receptors.PACAPitselfinhibitsK+amplitudeofdelayedrectifierK+channels,exhibitinganti-apoptoticactivityincerebellargranulecells.
References
NamBH,MoonJY,KimYO,etal.Structuralandfunctionalcharacterizationofpituitaryadenylylcyclase-activatingpolypeptide(PACAP)/PACAP-relatedpeptide(PRP)anditsreceptorinoliveflounder(Paralichthysolivaceus).CompBiochemPhysiolBBiochemMolBiol.2013Jan;164(1):18-28.PMID:23026070.
TamJK,LeeLT,ChengCH,etal.Discoveryofanewreproductivehormoneinteleosts:pituitaryadenylatecyclase-activatingpolypeptide-relatedpeptide(PRP).GenCompEndocrinol.2011Sep15;173(3):405-10.PMID:21703272.
VaudryD,Falluel-MorelA,BourgaultS,etal.Pituitaryadenylatecyclase-activatingpolypeptideanditsreceptors:20yearsafterthediscovery.PharmacolRev.2009Sep;61(3):283-357.PMID:19805477.
MeiYA,VaudryD,BasilleM,etal.PACAPinhibitsdelayedrectifierpotassiumcurrentviaacAMP/PKAtransductionpathway:evidencefortheinvolvementofIkintheanti-apoptoticactionofPACAP.EurJNeurosci.2004Mar;19(6):1446-58.PMID:15066141.
