Description
Prionpeptide(106-126)(PrP106-126)isasyntheticglycoproteinthatmimicsasegmentofcellularprionproteinexpressedinneuronsandothercells.Prp106-126formsamyloid-likefibrilsandupregulatesexpressionofIL-1β,TNF-α,andmatrixmetalloproteinases1,3,and11(MMP1/3/11)inastrocytesandmicroglia.Inothercellularmodels,PrP106-126increaseslevelsofROSandactivatesERK1/2,p38,andJNK1/2,amplifyingnormalPrPsignalingandcausingoxidativestressandneuronalinjury.PrP106-126alsobindsthep75neurotrophinreceptor(thelow-affinityNGFreceptor;p75NTR)and,separately,altersmicroglialphagocyticactivity.
References
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PietriM,CapriniA,Mouillet-RichardS,etal.OverstimulationofPrPCsignalingpathwaysbyprionpeptide106-126causesoxidativeinjuryofbioaminergicneuronalcells.JBiolChem.2006Sep22;281(38):28470-9.PMID:16864581.
Ciesielski-TreskaJ,GrantNJ,UlrichG,etal.Fibrillarprionpeptide(106-126)andscrapieprionproteinhamperphagocytosisinmicroglia.Glia.2004Apr15;46(2):101-15.PMID:15042579.
Della-BiancaV,RossiF,ArmatoU,etal.Neurotrophinp75receptorisinvolvedinneuronaldamagebyprionpeptide-(106-126).JBiolChem.2001Oct19;276(42):38929-33.PMID:11489911.
