Nivalenol is a Fusarium type B trichothecene mycotoxin. Nivalenol is cytotoxic to leukocytes, inhibiting cell proliferation, increasing IL-8 secretion, and decreasing MCP-1 secretion in an NF-κB-dependent manner. In macrophages and Jurkat T cells, nivalenol increases cytochrome c release and degradation of Bcl-2, stimulating caspase 3-mediated apoptosis. Additionally, nivalenol induces the breakdown of polyribosomes and inhibits polypeptide chain initiation in eukaryotes.
| Cas No. | 23282-20-4 |
|---|---|
| Purity | ≥99%, TLC |
| Formula | C15H20O7 |
| Formula Wt. | 312.32 |
| Melting Point | 127-130°C |
| Solubility | DMSO, Methanol, dichloromethane. Slightly soluble in water. |
| Appearance | White to off white powder |
| Store Temp | -20°C |
|---|---|
| Ship Temp | Ambient |
| MSDS | N3584 MSDS PDF |
|---|---|
| Info Sheet | N3584 Info Sheet PDF |
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