Oxytocinisanendogenouspeptideneurohormonethatdoesnotcrosstheblood-brainbarrier.Oxytocinbindstheoxytocinreceptor(OXTR)andexhibitsneuromodulatory,antinociceptive,antidepressant,anxiolytic,andotheractivities;itisinvolvedwithfeelingsoftrust,memory,intimacy,andfidelity.Oxytocinalsoinhibitsacid-sensingionchannelsandmaybeusedasabioMarkerofbonemineraldensity.
| CasNo. | 50-56-6 |
|---|---|
| Purity | ≥95% |
| Formula | C43H66N12O12S2 |
| FormulaWt. | 1007.2 |
| ChemicalName | L-Cysteinyl-L-tyrosyl-L-isoleucyl-L-glutaminyl-L-asparaginyl-L-cysteinyl-L-prolyl-L-leucylglycinamidecyclic(1-6)-disulfide |
| IUPACName | 1-[19-amino-7-(2-amino-2-oxoethyl)-10-(3-amino-3-oxopropyl)-13-butan-2-yl-16-[(4-hydroxyphenyl)methyl]-6,9,12,15,18-pentaoxo-1,2-dithia-5,8,11,14,17-pentazacycloicosane-4-carbonyl]-N-[1-[(2-amino-2-oxoethyl)amino]-4-methyl-1-oxopentan-2-yl]pyrrolidine-2-carboxamide |
| Synonym | Ocytocin;Interocine-S;Perlacton;Pitocin;Syntocinon;Orasthin;Oxystin;Partocon. |
| MeltingPoint | 192-194°C |
| Solubility | Solubleinwater,1-butanolor2-butanol. |
| Appearance | Whitetooff-whitepowder |
| StoreTemp | -20°C |
|---|---|
| ShipTemp | Ambient |
| InfoSheet | O9497InfoSheetPDF |
|---|
BreuilV,Panaia-FerrariP,FontasE,etal.Oxytocin,anewdeterminantofbonemineraldensityinpost-menopausalwomen:analysisoftheOPUScohort.JClinEndocrinolMetab.2014Apr;99(4):E634-41.PMID:24446658.
YuenKW,GarnerJP,CarsonDS,etal.Plasmaoxytocinconcentrationsarelowerindepressedvs.healthycontrolwomenandareindependentofcortisol.JPsychiatrRes.2014Apr;51:30-6.PMID:24405552.
QiuF,QiuCY,CaiH,etal.Oxytocininhibitstheactivityofacid-sensingionchannelsthroughthevasopressin-1areceptorinprimarysensoryneurons.BrJPharmacol.2014Feb15.[Epubaheadofprint].PMID:24641084.
EvansSL,DalMonteO,NobleP,etal.Intranasaloxytocineffectsonsocialcognition:Acritique.BrainRes.2013Nov14.[Epubaheadofprint].PMID:24239931.
