Description
Pancreastatinisanendogenouspeptidederivedfromchromogranin-Athatregulatesinsulinaction,inhibitinginsulinsecretionandincreasingglucagonsecretion.PancreastatinbindsandinhibitsGRP78,decreasinginsulin-stimulatedglucoseuptakeandexpressionofG6Pase.Thispeptidedisplayspro-diabeticactivityandinducesglycogenolysisandlipolysis.PancreastatinisalsousedasabioMarkertodetectneuroendocrinetumorsandshowssomecorrelationwithdiabetesandhypertension.
References
BiswasN,FrieseRS,GayenJR,etal.DiscoveryofanoveltargetforthedysglycemicchromograninAfragmentpancreastatin:interactionwiththechaperoneGRP78toinfluencemetabolism.PLoSOne.2014Jan20;9(1):e84132.PMID:24465394.
RustagiS,WarnerRR,DivinoCM.Serumpancreastatin:thenextpredictiveneuroendocrinetumormarker.JSurgOncol.2013Aug;108(2):126-8.PMID:23775817.
Sánchez-MargaletV,González-YanesC,NajibS,etal.MetaboliceffectsandmechanismofactionofthechromograninA-derivedpeptidepancreastatin.RegulPept.2010Apr9;161(1-3):8-14.PMID:20184923.