Pep-1isacell-penetratingpeptideusedtocarrylargeconjugatedstructuresacrosscellmembranes.Pep-1inhibitslowmolecularweighthyaluronanbindingtotoll-likereceptor4(TLR4)andotherreceptors.Pep-1alsodecreasesintestinalandcoloniclength,decreasesexpressionofIGF-1andepiregulin,anddecreasesintestinalepithelialcellproliferationinvivo.
| Purity | ≥95% |
|---|---|
| Formula | C136H195N35O33 |
| FormulaWt. | 2848.23 |
| Appearance | Whitetooffwhitepowder |
| StoreTemp | -20°C |
|---|---|
| ShipTemp | Ambient |
| InfoSheet | P1764InfoSheetPDF |
|---|
MeloniBP,CraigAJ,MilechN,etal.TheNeuroprotectiveEfficacyofCell-PenetratingPeptidesTAT,Penetratin,Arg-9,andPep-1inGlutamicAcid,KainicAcid,andInVitroIschemiaInjuryModelsUsingPrimaryCorticalNeuronalCultures.CellMolNeurobiol.2013Nov9.[Epubaheadofprint].PMID:24213248.
ThaeteLG,QuXW,JillingT,etal.Impactoftoll-likereceptor4deficiencyontheresponsetouterineischemia/reperfusioninmice.Reproduction.2013Apr29;145(5):517-26.PMID:23509372.
RiehlTE,EeX,StensonWF.Hyaluronicacidregulatesnormalintestinalandcolonicgrowthinmice.AmJPhysiolGastrointestLiverPhysiol.2012Aug1;303(3):G377-88.PMID:22556141.
BoboneS,PiazzonA,OrioniB,etal.Thethinlinebetweencell-penetratingandantimicrobialpeptides:thecaseofPep-1andPep-1-K.JPeptSci.2011May;17(5):335-41.PMID:21294230.
