Peptide401isanantimicrobialpeptide(AMP)derivedfromthevenomofbeesandwasps.Peptide401inducesmastcelldegranulation,activatinghistaminereleasefromperitonealmastcells.Additionally,peptide401exhibitssomeanti-inflammatoryactivity,decreasingpawedemainanimalmodels.
| CasNo. | 32908-73-9 |
|---|---|
| Purity | ≥95% |
| Formula | C110H188N40O24S4 |
| FormulaWt. | 2583.28 |
| Synonym | MastCellDegranulatingPeptide |
| StoreTemp | -20°C |
|---|---|
| ShipTemp | Ambient |
| InfoSheet | P0276InfoSheetPDF |
|---|
BanksBE,DempseyCE,VernonCA,etal.Anti-inflammatoryactivityofbeevenompeptide401(mastcelldegranulatingpeptide)andcompound48/80resultsfrommastcelldegranulationinvivo.BrJPharmacol.1990Feb;99(2):350-4.PMID:2328399.
EnnisM,AtkinsonG,PearceFL.Inhibitionofhistaminereleaseinducedbycompound48/80andpeptide401inthepresenceandabsenceofcalcium.Implicationsforthemodeofactionofanti-allergiccompounds.AgentsActions.1980Jun;10(3):222-8.PMID:6157320.
HansonJM,MorleyJ,Soria-HerreraC.Anti-inflammatorypropertyof401(MCD-peptide),apeptidefromthevenomofthebeeApismellifera(L.).BrJPharmacol.1974Mar;50(3):383-92.PMID:4152780.
