Description
Peptide F is an endogenous pro-enkephalin peptide found predominantly in the adrenal medulla; it is typically co-secreted with epinephrine. Peptide F exhibits immunostimulatory effects. In clinical settings, high levels of peptide F have been found in physically fit subjects, suggesting a potential link between fitness and immune function.
References
Kraemer WJ, Mastro AM, Gordon SE, et al. Responses of plasma proenkephalin peptide F in rats following 14 days of spaceflight. Aviat Space Environ Med. 2004 Feb;75(2):114-7. PMID: 14960045.
Triplett-McBride NT, Mastro AM, McBride JM, et al. Plasma proenkephalin peptide F and human B cell responses to exercise stress in fit and unfit women. Peptides. 1998;19(4):731-8. PMID: 9622029.