PeptideTisanoctapeptidefragmentoftheV2regionofHIV-1glycoproteingp120.PeptideTexhibitsanti-inflammatoryactivity,decreasinginflammationandactingasapotentialtreatmentforpsoriasis.PeptideTalsoinhibitsHIVentry,blockingbindingandinfectionofHIVstrainsthatrequireCCR5forentry.PeptideTalsodisplayssomeneuroprotectiveactivity,improvingcognitiveperformanceinneuroAIDSsubjects.
| CasNo. | 106362-32-7 |
|---|---|
| Purity | ≥98% |
| Formula | C35H55N9O16 |
| FormulaWt. | 857.86 |
| ChemicalName | N-(N-(N2-(N-(N-(N-(N-L-alanyl-L-seryl)-L-thronyl)-L-threonyl)-L-threonyl)-L-asparaginyl)-L-tyrosyl)-L-Threonine |
| IUPACName | (2S,3R)-2-[[(2S)-2-[[(2S)-4-amino-2-[[(2S,3R)-2-[[(2S,3R)-2-[[(2S,3R)-2-[[(2S)-2-[[(2S)-2-aminopropanoyl]amino]-3-hydroxypropanoyl]amino]-3-hydroxybutanoyl]amino]-3-hydroxybutanoyl]amino]-3-hydroxybutanoyl]amino]-4-oxobutanoyl]amino]-3-(4-hydroxyphenyl)propanoyl]amino]-3-hydroxybutanoicacid |
| StoreTemp | -20°C |
|---|---|
| ShipTemp | Ambient |
| InfoSheet | P1760InfoSheetPDF |
|---|
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D"ursiA,CaliendoG,PerissuttiE,etal.Conformation-activityrelationshipofpeptideTandnewpseudocyclichexapeptideanalogs.JPeptSci.2007Jun;13(6):413-21.PMID:17486694.
PolianovaMT,RuscettiFW,PertCB,etal.Chemokinereceptor-5(CCR5)isareceptorfortheHIVentryinhibitorpeptideT(DAPTA).AntiviralRes.2005Aug;67(2):83-92.PMID:16002156.
RuffMR,Melendez-GuerreroLM,YangQE,etal.PeptideTinhibitsHIV-1infectionmediatedbythechemokinereceptor-5(CCR5).AntiviralRes.2001Oct;52(1):63-75.PMID:11530189.
HeseltinePN,GoodkinK,AtkinsonJH,etal.Randomizeddouble-blindplacebo-controlledtrialofpeptideTforHIV-associatedcognitiveimpairment.ArchNeurol.1998Jan;55(1):41-51.PMID:9443710.
