Busulfanisanalkylsulfonatethatexhibitsanticancerchemotherapeuticactivity.BusulfanisanalkylatingagentthatattachesanalkylgrouptotheN7positionofguaninebases,inhibitingDNAreplication;itisclinicallyusedtotreatchronicmyelogenousleukemia(CML).Invitro,busulfaninhibitsgrowthofpromyelocyticleukemiacells.ThiscompoundmayalsoinducesenescenceinnormalcellsthroughactivationofERKandp38MAPKsignaling.
| CasNo. | 55-98-1 |
|---|---|
| Purity | ≥98% |
| Formula | C6H14O6S2 |
| FormulaWt. | 246.30 |
| ChemicalName | 1,4-Butanedioldimethanesulfonateesters |
| IUPACName | 4-methylsulfonyloxybutylmethanesulfonate |
| Synonym | Busulphan |
| MeltingPoint | 287°C |
| Solubility | Solubleinacetone(22mg/mL),ethanol,orDMSO.Insolubleinwater. |
| Appearance | Whitecrystallinepowder |
| StoreTemp | Ambient |
|---|---|
| ShipTemp | Ambient |
| MSDS | B7973MSDSPDF |
|---|---|
| InfoSheet | B7973InfoSheetPDF |
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