CEP-32496isakinaseinhibitorthathasmultikinasebindingactivitybutremainsselectivelycytotoxicformutant(V600E)B-Raf(versusWT);itexhibitsanticancerchemotherapeuticactivity.AlsocontributingtotheABIlityofCEP-32496toinhibitcellproliferation,thiscompoundinhibitspMEKandmERKinanimalmodelswithtumorscontainingthemutantB-Raf.
| CasNo. | 1188910-76-0 |
|---|---|
| Purity | ≥98% |
| Formula | C24H22F3N5O5 |
| FormulaWt. | 517.46 |
| ChemicalName | Urea,N-[3-[(6,7-dimethoxy-4-quinazolinyl)oxy]phenyl]-N-[5-(2,2,2-trifluoro-1,1-dimethylethyl)-3-isoxazolyl]- |
| IUPACName | 1-[3-(6,7-dimethoxyquinazolin-4-yl)oxyphenyl]-3-[4-(1,1,1-trifluoro-2-methylpropan-2-yl)-1,2-oxazol-3-yl]urea |
| Solubility | DMSO9mg/mL |
| Appearance | Whitetooffwhitepowder |
| StoreTemp | -20°C |
|---|---|
| ShipTemp | Ambient |
| MSDS | C1660MSDSPDF |
|---|---|
| InfoSheet | C1660InfoSheetPDF |
| Brochures | Ras-Raf-MEK-ERKPathwayBooklet |
JamesJ,RuggeriB,ArmstrongRC,etal.CEP-32496:anovelorallyactiveBRAF(V600E)inhibitorwithselectivecellularandinvivoantitumoractivity.MolCancerTher.2012Apr;11(4):930-41.PMID:22319199.
RowbottomMW,FaraoniR,ChaoQ,etal.Identificationof1-(3-(6,7-dimethoxyquinazolin-4-yloxy)phenyl)-3-(5-(1,1,1-trifluoro-2-methylpropan-2-yl)isoxazol-3-yl)ureahydrochloride(CEP-32496),ahighlypotentandorallyefficaciousinhibitorofV-RAFmurinesarcomaviraloncogenehomologueB1(BRAF)V600E.JMedChem.2012Feb9;55(3):1082-105.PMID:22168626.
