Cetrimide is a mix of quaternary ammonium salts that exhibits antiseptic and anticancer chemotherapeutic activities. Cetrimide acts as a cationic detergent, altering the mitochondrial membrane potential and inducing pore formation in membranes. Cetrimide bromide inhibits H+ ATP synthase, inducing mitochondrial membrane depolarization and caspase activation and inhibiting proliferation in cellular and animal models of head and neck cancers.
| Cas No. | 57-09-0 |
|---|---|
| Purity | ≥98% |
| Formula | C19H42BrN |
| Formula Wt. | 364.45 |
| Chemical Name | N,N,N-Trimethyl-1-hexadecanaminium bromide |
| IUPAC Name | hexadecyl(trimethyl)azanium;bromide |
| Synonym | Cetrimonium Bromide; Bromat; Cetab; Lissolamine V; Micol; Quamonium, Hexadecyltrimethylammonium bromide |
| Melting Point | 248-251°C |
| Solubility | Soluble in 1 M water at 20oC. Sparingly soluble in acetone. |
| Appearance | White Crystal Powder |
| Store Temp | Ambient |
|---|---|
| Ship Temp | Ambient |
| MSDS | C1878 MSDS PDF |
|---|---|
| Info Sheet | C1878 Info Sheet PDF |
Ito E, Yip KW, Katz D, et al. Potential use of cetrimonium bromide as an apoptosis-promoting anticancer agent for head and neck cancer. Mol Pharmacol. 2009 Nov;76(5):969-83. PMID: 19654225.
Bragadin M, Dell'Antone P. Mitochondrial bioenergetics as affected by cationic detergents. Arch Environ Contam Toxicol. 1996 Feb;30(2):280-4. PMID: 8593085.
