Cetrimideisamixofquaternaryammoniumsaltsthatexhibitsantisepticandanticancerchemotherapeuticactivities.Cetrimideactsasacationicdetergent,alteringthemitochondrialmembranepotentialandinducingporeformationinmembranes.CetrimidebromideinhibitsH+ATPsynthase,inducingmitochondrialmembranedepolarizationandcaspaseactivationandinhibitingproliferationincellularandanimalmodelsofheadandneckcancers.
| CasNo. | 57-09-0 |
|---|---|
| Purity | ≥98% |
| Formula | C19H42BrN |
| FormulaWt. | 364.45 |
| ChemicalName | N,N,N-Trimethyl-1-hexadecanaminiumbromide |
| IUPACName | hexadecyl(trimethyl)azanium;bromide |
| Synonym | CetrimoniumBromide;Bromat;Cetab;LissolamineV;Micol;Quamonium,Hexadecyltrimethylammoniumbromide |
| MeltingPoint | 248-251°C |
| Solubility | Solublein1Mwaterat20oC.Sparinglysolubleinacetone. |
| Appearance | WhiteCrystalPowder |
| StoreTemp | Ambient |
|---|---|
| ShipTemp | Ambient |
| MSDS | C1878MSDSPDF |
|---|---|
| InfoSheet | C1878InfoSheetPDF |
ItoE,YipKW,KatzD,etal.Potentialuseofcetrimoniumbromideasanapoptosis-promotinganticanceragentforheadandneckcancer.MolPharmacol.2009Nov;76(5):969-83.PMID:19654225.
BragADInM,Dell"AntoneP.Mitochondrialbioenergeticsasaffectedbycationicdetergents.ArchEnvironContamToxicol.1996Feb;30(2):280-4.PMID:8593085.
