CGK733 is an inhibitor of ATM and ATR kinases that prevents double-stranded DNA strand break repair. CGK733 displays anticancer activity, decreases expression of p21 in senescent cells and inducing cell death in cancer cells and fibroblasts.
| Cas No. | 905973-89-9 |
|---|---|
| Purity | ≥98% |
| Formula | C23H18Cl3FN4O3S |
| Formula Wt. | 555.83 |
| IUPAC Name | 2,2-Diphenyl-N-(2,2,2-trichloro-1-{[(4-fluoro-3-nitrophenyl)carbamothioyl]amino}ethyl)acetamide |
| Synonym | CGK733, ATM/ATR Kinase Inhibitor |
| Store Temp | -20°C |
|---|---|
| Ship Temp | Ambient |
| Info Sheet | C2540 Info Sheet PDF |
|---|
Jekimovs C, Bolderson E, Suraweera A, et al. Chemotherapeutic compounds targeting the DNA double-strand break repair pathways: the good, the bad, and the promising. Front Oncol. 2014 Apr 22;4:86. PMID: 24795863.
Alao JP, Sunnerhagen P. The ATM and ATR inhibitors CGK733 and caffeine suppress cyclin D1 levels and inhibit cell proliferation. Radiat Oncol. 2009 Nov 10;4:51. PMID: 19903334.
