Reactivationofp53andinductionoftumorcellapoptosis(RITA)isanactivatorofp53thatexhibitsanticancerchemotherapeuticandanti-angiogenicactivities.Invivo,RITAdownregulatesexpressionofVEGF,HIF-1α,p21,andHDM2.Incellularandanimalmodelsofneuroblastoma,RITAinhibitsexpressionofN-Myc,AurK,Mcl-1,Bcl-2,MDM2,andMDMX,inducingapoptosisandinhibitinggrowth.Similareffectsareobservedinmodelsofgastrointestinalstromaltumorsandcervicalcarcinoma.
| CasNo. | 213261-59-7 |
|---|---|
| Purity | ≥98% |
| Formula | C14H12O3S2 |
| FormulaWt. | 292.37 |
| IUPACName | [5-[5-[5-(hydroxymethyl)thiophen-2-yl]furan-2-yl]thiophen-2-yl]methanol |
| Synonym | Reactivationofp53andinductionoftumorcellapoptosis |
| StoreTemp | -20°C |
|---|---|
| ShipTemp | Ambient |
| InfoSheet | R3476InfoSheetPDF |
|---|
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