RKI-1447isaninhibitorofROCK1/2thatexhibitsanticancerchemotherapeuticactivity.RKI-1447alsodisplaysanti-metastaticpotential,suppressingphosphorylationofMLC-2,MYPT-1,inhibitingformationofactinstressfibers,andpreventingmigration,invasion,andgrowthofbreastcancercellsandtumors.
| CasNo. | 1342278-01-6 |
|---|---|
| Purity | ≥98% |
| Formula | C16H14N4O2S |
| FormulaWt. | 326.37 |
| IUPACName | 1-[(3-hydroxyphenyl)methyl]-3-(4-pyridin-4-yl-1,3-thiazol-2-yl)urea |
| Synonym | RKI1447 |
| Appearance | Whitetooffwhitepowder |
| StoreTemp | -20°C |
|---|---|
| ShipTemp | Ambient |
| InfoSheet | R4132InfoSheetPDF |
|---|
PatelRA,ForinashKD,PiredduR,etal.RKI-1447isapotentinhibitoroftheRho-associatedROCKkinaseswithanti-invasiveandantitumoractivitiesinbreastcancer.CancerRes.2012Oct1;72(19):5025-34.PMID:22846914.
