Procarbazineisahydrazinederivativethatexhibitsanticancerchemotherapeuticactivity.ProcarbazineactsasaDNAalkylatorandinducesdoublestrandedDNAbreaksandcausesoxidativedamage.Clinically,procarbazineisusedtotreatHodgkin’slymphomaandbraincancers.Thiscompoundalsoinhibitsmonoamineoxidase(MAO).
| CasNo. | 366-70-1 |
|---|---|
| Purity | ≥97% |
| Formula | C12H19N3O•HCl |
| FormulaWt. | 257.76 |
| ChemicalName | N-(1-Methylethyl)-4-[(2-methylhydrazino)methyl]-benzamidehydrochloride |
| IUPACName | 4-[(2-methylhydrazinyl)methyl]-N-propan-2-ylbenzamide;hydrochloride |
| Synonym | Matulane;Natulan |
| MeltingPoint | 223-226°C |
| Solubility | Solubleinwater. |
| Appearance | Whitecrystallinepowder |
| StoreTemp | Ambient |
|---|---|
| ShipTemp | Ambient |
| MSDS | P6858MSDSPDF |
|---|---|
| InfoSheet | P6858InfoSheetPDF |
OgawaK,HirakuY,OikawaS,etal.MolecularmechanismsofDNAdamageinducedbyprocarbazineinthepresenceofCu(II).MutatRes.2003Aug5;539(1-2):145-55.PMID:12948823.
KyrtopoulosSA,AndersonLM,ChhabraSK,etal.DNAadductsandthemechanismofcarcinogenesisandcytotoxicityofmethylatingagentsofenvironmentalandclinicalsignificance.CancerDetectPrev.1997;21(5):391-405.PMID:9307842.
