LKT/PURVALANOL A/P8270/5 mg-免疫在线蚂蚁淘旗下平台

商品详细LKT/PURVALANOL A/P8270/5 mg

LKT/PURVALANOL A/P8270/5 mg

商品编号： P8270-5mg

品牌： lktlabs

市场价： ¥8040.00

美元价： 4824.00

产地：美国(厂家直采)

公司：

产品分类：临床研究

公司分类： clinical_research

联系Q Q： 3392242852

电话号码： 4000-520-616

电子邮箱： info@ebiomall.com

立即询价

商品介绍

ProductIDP8270

CasNo.212844-53-6

Purity≥98%

Description
ProductInfo
ShippingandStorage
Downloads
References

Description

PurvalanolAisapurinederivativeanticancercompoundthatinhibitscyclin-dependentkinases(CDKs).PurvalanolAinducescellcyclearrestandapoptosisinbreastcancercellsandisclinicallyusedtoincreaseefficacyofco-admiNISTeredchemotherapeuticsbyinhibitingbreastcancerresistanceprotein(ABCG2)transport.InADIpose-derivedstemcells,purvalanolAinhibitsCDK1/Cdc2andCDK2/cyclinE,alteringdifferentiationpotential.PurvalanolAalsoinhibitsJAK2/STATactivationandRNApolymeraseIIactivityingastricadenocarcinomacells.Additionally,thiscompounddecreaseshumanT-cellleukemiavirustype1(HTLV-1)proliferation.

ProductInfo

CasNo.	212844-53-6
Purity	≥98%
Formula	C₁₉H₂₅ClN₆O
FormulaWt.	388.90
ChemicalName	6-[(3-Chloro)anilino]-2(1R)-(isopropyl-2-hydroxyethylamino)-9-isopropylpurine
IUPACName	(2R)-2-[[6-(3-chloroanilino)-9-propan-2-ylpurin-2-yl]amino]-3-methylbutan-1-ol
Synonym	NG-60;Purv
Solubility	Solubleinmethylenechloride(50mg/mL),DMSOandmethanol.
Appearance	YellowPowder

ShippingandStorage

StoreTemp	-20°C
ShipTemp	Ambient

Downloads

MSDS	P8270MSDSPDF
InfoSheet	P8270InfoSheetPDF

References

ObakanP,ArısanED,ÖzfilizP,etal.PurvalanolAisastrongapoptoticinducerviaactivatingpolyaminecatabolicpathwayinMCF-7estrogenreceptorpositivebreastcancercells.MolBiolRep.2014Jan;41(1):145-54.PMID:24190492.

HofmanJ,AhmadimoghaddamD,HahnovaL,etal.OlomoucineIIandpurvalanolAinhibitABCG2transporterinvitroandinsituandsynergisticallypotentiatecytostaticeffectofmitoxantrone.PharmacolRes.2012Mar;65(3):312-9.PMID:22173067.

ParkH,ChoJA,LimEH,etal.CellcycleregulatorsarecriticalformaintainingthedifferentiationpotentialandimmaturityinAdipogenesisofadipose-derivedstemcells.Differentiation.2011Oct;82(3):136-43.PMID:21764208.

IizukaD,OguraA,KuwabaraM,etal.PurvalanolAinducesapoptosisanddownregulationofantiapoptoticproteinsthroughabrogationofphosphorylationofJAK2/STAT3andRNApolymeraseII.AnticancerDrugs.2008Jul;19(6):565-72.PMID:18525315.

AgbottahE,YehWI,BerroR,etal.Twospecificdrugs,BMS-345541andpurvalanolAinduceapoptosisofHTLV-1infectedcellsthroughinhibitionoftheNF-kappaBandcellcyclepathways.AIDSResTher.2008Jun10;5:12.PMID:18544167.

品牌介绍

LKT Labs LKT Labs 是一家专注于防癌抗癌特殊化学品研究和开发的公司。主要提供：癌症药物、药物发现试剂盒、天然产物、广泛的生命科学研究试剂、定制合成。美国LKT Labs 是1988年在美国成立的，为全球提供先端的药物研发试剂、试剂盒、委托合成，并为药物生产企业提供原料，最近几年在农药、水产养殖业有很大程度的开发。在LKT Labs 可以找到在其他地方找不到的产品。试剂